THE STABILITY OF THE ACID-BASE EQUILIBRIUM OF THE BLOOD IN NATURALLY NEPHROPATHIC ANIMALS AND THE EFFECT ON RENAL FUNCTION OF CHANGES IN THIS EQUILIBRIUM
Open Access
- 1 October 1918
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 28 (4) , 501-516
- https://doi.org/10.1084/jem.28.4.501
Abstract
1. The naturally acquired chronic glomerulonephropathies of the dog are not due to an acid intoxication. 2. Such an injury renders the acid-base equilibrium of the animal unstable and susceptible to an agent such as an anesthetic which tends to induce an acid intoxication. 3. When naturally nephropathic animals are anesthetized by Grehant's anesthetic, the principal anesthetic ingredient of which is chloroform, the animals develop an acid intoxication, and become anuric and non-responsive to diuretic substances. 4. The development of the anuria has been constantly associated with swelling, vacuolation, and necrosis of the convoluted tubule epithelium. 5. In the kidneys of these animals there occurs an accumulation of fat which is largely confined to the ascending limbs of Henle's loops and which shows a quantitative relation with the degree of acid intoxication.Keywords
This publication has 4 references indexed in Scilit:
- Occasional Papers of the Museum of Zoology, University of Michigan . Nos. 1-35, 1913- 17 (each separately paged). Ann Arbor, published by the University.Science, 1917
- A Pathological and Physiological Study of the naturally Nephropathic Kidney of the Dog, rendered acutely Nephropathic by Uranium or by an Anesthetic : Part II.1916
- A Pathological Study of the naturally acquired Chronic Nephropathy of the Dog : Part I.1916
- Reliability of Dogs as Subjects for experimental Nephritis.1914