Time to abandon dogma: CD14 is expressed by non‐myeloid lineage cells

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Abstract
CD14 is a pattern recognition receptor; its important role in innate immunity is reviewed here. Since its discovery and subsequent classification at the first leucocyte typing workshop in 1982, CD14 has been thought of as a leucocyte differentiation antigen. However, it has become clear that CD14 is also expressed by many non‐myeloid cells, and the evidence for this is presented. The possible role of the presence of low copy number CD14 on non‐myeloid cells is discussed. It is time to acknowledge CD14 as an ubiquitous molecule and abandon the position that it is expressed by myeloid cells alone.
Funding Information
  • Royal Australasian College of Physicians