Metal-ion oxidations in solution. Part XIX. Redox pathways in the oxidation of penicillamine and glutathione by chromium(VI)

Abstract
Three moles of penicillamine or glutathione are required to reduce Cr(VI) to Cr(III). The kinetics and mechanism of the redox reaction were studied using the stopped-flow method. The reaction proceeds via the formation of a transient intermediate (K1) which decomposes either in a proton-catalyzed pathway or by reaction with a 2nd mole of thiol. Several Cr(III) products were identified by ion-exchange methods. The significance of the 2nd order pathways in these reactions is discussed.

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