Lack of Response of Murine Peritoneal Macrophages toin vitroActivation by Muramyl Dipeptide (MDP)
- 1 March 1990
- journal article
- research article
- Published by Wiley in Microbiology and Immunology
- Vol. 34 (3) , 323-335
- https://doi.org/10.1111/j.1348-0421.1990.tb01013.x
Abstract
Peritoneal exudate macrophages from mice, rats, and guinea pigs were assessed using six different parameters of macrophage activation to determine whether the cells were stimulated under similar experimental conditions. Peritoneal exudate macrophages from mice, irrespective of strain, were far less responsive to a variety of in vitro stimulatory effects of N-acetylmuramyl-l-alanyl-d-isoglutamine than those from rats or guinea pigs, while no significant differences were noted with the reactivity to stimulation by endotoxic lipopolysaccharide. We conclude that macrophage activation by MDP in vitro is species dependent.This publication has 36 references indexed in Scilit:
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