A Double-Blind Evaluation of Antihypertensive Drugs

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Abstract
This statistically analyzed study was begun in January 1956. One group of patients received placebo and ergot alkaloids parenterally. Another group received ergot alkaloids, guanethidine, alpha-methyldopa, methysergide, spironolactone, and spironolactone and reserpine orally. Hypotensive effect of these agents is described. Parenteral placebo caused a significant decrease in systolic pressure for 139 weeks and in diastolic pressure for 179 weeks. Oral placebo in those with blood pressure less than 200/120 mm Hg caused no decrease, while those whose blood pressure exceeded 200/120 mm Hg sustained a decrease. Antihypertensive therapy is described. A statistical base line for evaluating antihypertensives is established.

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