New approaches to the study of angiotensin tachyphylaxis.

  • 1 July 1977
    • journal article
    • Vol. 52  (7) , 446-8
Abstract
Of the various mechanisms proposed to explain the development of tachyphylaxis, the initial step of drug-receptor interaction has received the most attention. The present study suggests that the affinity of angiotensin II itself or an angiotensin analogue for the angiotensin receptor is a determing factor in the development of tachyphylaxis. The concept of negative cooperativity is introduced as a consequence of the observed correlation in the present study between slopes of less than unity as determined in Hill plots and the development of tachyphylaxis.

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