Rational Design and Synthesis of Novel, Potent Bis-phenylamidine Carboxylate Factor Xa Inhibitors
- 1 January 1998
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 41 (1) , 53-62
- https://doi.org/10.1021/jm970485a
Abstract
No abstract availableKeywords
This publication has 10 references indexed in Scilit:
- X-ray Structure of Active Site-inhibited Clotting Factor XaPublished by Elsevier ,1996
- Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and TrpScience, 1996
- Factor Xa Inhibitors as Novel Antithrombotic Agents: Facts and PerspectivesCardiovascular Drug Reviews, 1994
- Dibasic (Amidinoaryl)propanoic Acid Derivatives as Novel Blood Coagulation Factor Xa InhibitorsJournal of Medicinal Chemistry, 1994
- Strategies for anticoagulation with synthetic protease inhibitors. Xa inhibitors versus thrombin inhibitorsThrombosis Research, 1980
- Synthetic inhibitors of serine proteinases XXIII. Inhibition of factor Xa by diamidinesThrombosis Research, 1980
- Optimization of conditions for the catalytic effect of the factor IXa - Factor VIII complexThrombosis Research, 1979
- Rapid chromatographic technique for preparative separations with moderate resolutionThe Journal of Organic Chemistry, 1978
- New aromatic diamidines with central .alpha.-oxyalkane or .alpha.,.omega.-dioxyalkane chains. Structure-activity relations for the inhibition of trypsin, pancreatic kallikrein, and thrombin and for the inhibition of the overall coagulation processJournal of Medicinal Chemistry, 1975
- The Chemistry of Imidates.Chemical Reviews, 1961