Transcriptional silencing and thermoregulation of gene expression in Escherichia coli
- 1 April 1990
- journal article
- Published by Springer Nature in Nature
- Vol. 344 (6267) , 682-685
- https://doi.org/10.1038/344682a0
Abstract
Expression of specific adhesive properties by bacteria in general seems to be regulated to fit the environmental conditions. An example is the transcriptional regulation of digalactoside-specific binding by uropathogenic strains of Escherichia coli. The fimbrial structures (pili) on the bacterial surface carry the adhesin and are present during growth at 37 degrees C but are not produced by cells at lower temperatures, such as 25 degrees C. Thermoregulation of expression is due to temperature-dependent transcription of a regulatory cistron in the pilus-adhesin gene cluster. We have now identified and characterized a new regulatory locus (drdX) and show that a histone-like bacterial protein has an important role in this novel example of thermoregulation of transcription.Keywords
This publication has 26 references indexed in Scilit:
- Regulatory genes in the thermoregulation of Escherichia coli pili gene transcription.Genes & Development, 1989
- Proteins from the prokaryotic nucleoid: primary and quaternary structure of the 15‐kD Escherichia coli DNA binding protein H‐NSMolecular Microbiology, 1988
- Identification, cloning, nucleotide sequence and chromosomal map location of hns, the structural gene for Escherichia coli DNA-binding protein H-NSMolecular Genetics and Genomics, 1988
- The physical map of the whole E. coli chromosome: Application of a new strategy for rapid analysis and sorting of a large genomic libraryCell, 1987
- Histonelike proteins of bacteria.Microbiological Reviews, 1987
- A DNA-binding protein fromE. coliisolation, characterization and its relationship with proteins H1 and B1Biochemical and Biophysical Research Communications, 1984
- Hla, anE. coliDNA-binding protein which accumulates in stationary phase, strongly compacts DNAin vitroNucleic Acids Research, 1984
- Analysis of gene control signals by DNA fusion and cloning in Escherichia coliJournal of Molecular Biology, 1980
- Histone-like proteins in the purified Escherichia coli deoxyribonucleoproteinNucleic Acids Research, 1977
- Two Heat-Resistant, Low Molecular Weight Proteins from Escherichia coli That Stimulate DNA-Directed RNA SynthesisProceedings of the National Academy of Sciences, 1972