Sensitivity of isolates of Trichinella to the drug thiabendazole

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Abstract
The sensitivity of 3 isolates of T. spiralis (from pig, polar bear and wolverine) and T. spiralis var. pseudospiralis to the anthelmintic thiabendazole (TBZ) was studied in male CD-1 mice. In vitro larval release by female worms isolated on day 7 following drug treatment (2-7 days) with various drug dosages (0.01-0.06%) showed that TBZ treatment resulted in sterility or a decrease in fecundity of the worms. Females of the pig isolate and T. spiralis var. pseudospiralis were chemosterilized with 0.05% TBZ and at 0.03% so were the 2 Arctic isolates (polar bear and wolverine), but chemosterilization was not permanent. Drug treatment during the disseminating phase (4-20 days) with low dosages (0.03-0.1%) was highly effective in reducing the number of muscle larvae at 40 days postinfection, a reduction that was similar for all Trichinella. Drug treatments (0.03-0.5%) during the early muscle phase (20-40 days) were ineffective with low dosages (< 0.15%), but with a higher dosage (0.5%) 99 and 100% efficacy were noted for the 2 Arctic isolates and T. spiralis var. pseudospiralis, respectively. Larvae recovered at high dosages (> 0.15%), were not infective to mice. Treatments with dosages of 0.03-0.1% from 40 to 60 days postinfection were only effective against the Arctic isolates. Of all the Trichinella studied, the pig isolate was the least sensitive to parenteral treatment.

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