Anti-receptor Antibodies Mimic the Effect of Insulin to Down-Regulate Insulin Receptors in Cultured Human Lymphoblastoid (IM-9) Cells
- 1 January 1984
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 58 (1) , 182-186
- https://doi.org/10.1210/jcem-58-1-182
Abstract
Autoantibodies directed against the insulin receptor mimicked the effect of insulin to down-regulate insulin receptors in IM-9 cells. This down-regulation occurred at 37 C, but not at 15 or 22 C. As with insulin itself, antireceptor antibodies caused down-regulation by accelerating the rate of receptor degradation. Down-regulation induced by antireceptor antibody may play a role in desensitizing target cells to the effects of insulin.Keywords
This publication has 10 references indexed in Scilit:
- Clinical disorders associated with autoantibodies to the insulin receptor. Simulation by passive transfer of immunoglobulins to rats.Journal of Clinical Investigation, 1983
- Hypoglycemia Associated with Antibodies to the Insulin ReceptorNew England Journal of Medicine, 1982
- Decreased Insulin Binding in Cultured Lymphocytes from Two Patients with Extreme Insulin Resistance*Journal of Clinical Endocrinology & Metabolism, 1982
- Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own ReceptorScience, 1982
- Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation.Proceedings of the National Academy of Sciences, 1981
- Antibody-induced Desensitization of the Insulin ReceptorJournal of Clinical Investigation, 1980
- The Underlying Insulin Receptor in Patients with Antireceptor Autoantibodies: Demonstration of Normal Binding and Immunological PropertiesJournal of Clinical Endocrinology & Metabolism, 1979
- Desensitization of the insulin receptor at an early postreceptor step by prolonged exposure to antireceptor antibodyProceedings of the National Academy of Sciences, 1979
- The Evolving Clinical Course of Patients with Insulin Receptor Autoantibodies: Spontaneous Remission or Receptor Proliferation with HypoglycemiaJournal of Clinical Endocrinology & Metabolism, 1978
- Myasthenic Antibodies Cross-Link Acetylcholine Receptors to Accelerate DegradationNew England Journal of Medicine, 1978