The bioavailability of flufenamic acid from aluminum flufenamate tablet and flufenamic acid capsule, and the influence of food and aluminum hydroxide gel.

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Abstract
The bioavailabilities in humans of flufenamic acid (1) [an antiinflammatory agent used in the treatment of rheumatoid arthritis] from a commercial aluminum flufenamate (2) tablet and 1 capsule were estimated by measuring urinary excretion of 1 and its metabolites fluorometrically. The dissolution rates of 1 from both dosage forms were also determined. The effects of concomitant intake of food or antacid on the bioavailabilities from the 2 tablet and the 1 capsule were investigated. The extent of 1 bioavailability from the 2 tablet was < 30% of that from the 1 capsule. Dissolution tests suggested that the low bioavailability of 1 from 2 tablet resulted from the extremely slow release of 1 from the 2 complex. Intake of a standard meal retarded 1 absorption from 1 capsule but did not affect that from the 2 tablet. Ingestion of dried aluminum hydroxide gel granules had little effect on 1 bioavailability from the 1 capsule.

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