ESTROGEN-INDUCED FORMATION OF UTERINE RIBOSOMES
- 1 August 1964
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 52 (2) , 439-446
- https://doi.org/10.1073/pnas.52.2.439
Abstract
Ribosomes with a sedimentation coefficient of 78S are in greater abundance in the cytoplasm of estrogen-stimulated uterine cells than in those deprived of hormone. From 4 to 24 hr. following estrogenic stimulation, newly formed ribosomes appear in the cytoplasm, and this represents a means whereby steroid hormones can regulate the protein-synthesizing apparatus of the cells. Studies of uridine-H3 labeling of ribosomes following estrogenic stimulation indicate clearly that the rate of ribosome formation has been linearly accelerated in comparison to controls. This may be of interest to those concerned with the kinetics of ribosome formation. The estrogenic acceleration of rate of uterine ribosome formation is an actinomycin D-and puromycin-sensitive process. These findings are interpreted as representing a secondary response of the uterus to the DNA-dependent, primary action of estrogen, which may be gene activation or derepression.Keywords
This publication has 16 references indexed in Scilit:
- RNA Synthesis in Rat Seminal Vesicles: Stimulation by TestosteroneScience, 1964
- POLYRIBOSOMES AND MORPHOLOGY IN NEUROSPORA CRASSAProceedings of the National Academy of Sciences, 1964
- THE EFFECT OF ACTINOMYCIN ON RIBOSOME FORMATION IN HELA CELLSProceedings of the National Academy of Sciences, 1964
- Site of Protein Synthesis in the Hen OviductNature, 1964
- HYDROCORTISONE-STIMULATED SYNTHESIS OF NUCLEAR RNA IN ENZYME INDUCTIONProceedings of the National Academy of Sciences, 1963
- THE ROLE OF RNA SYNTHESIS IN EARLY ESTROGEN ACTIONProceedings of the National Academy of Sciences, 1963
- PREVENTION OF HORMONE ACTION BY LOCAL APPLICATION OF ACTINOMYCIN DProceedings of the National Academy of Sciences, 1963
- THE NATURE OF THE RNA RESPONSE TO ESTRADIOL ADMINISTRATION BY THE UTERUS OF THE RATProceedings of the National Academy of Sciences, 1963
- AN EFFECT OF TESTOSTERONE ON AMINO ACID INCORPORATION BY PROSTATIC RIBONUCLEOPROTEIN PARTICLESProceedings of the National Academy of Sciences, 1962
- DIRECT EVIDENCE FOR NUCLEAR SYNTHESIS OF CYTOPLASMIC RIBOSE NUCLEIC ACIDProceedings of the National Academy of Sciences, 1955