Antiplasmodial action and chemical constitution IX. Carbinolamines derived from 6:7-dimethylquinoline
Open Access
- 26 October 1948
- journal article
- Published by The Royal Society in Proceedings of the Royal Society of London. B. Biological Sciences
- Vol. 135 (880) , 271-292
- https://doi.org/10.1098/rspb.1948.0011
Abstract
This communication completes this series of investigations. Ten carbinolamines derived from 6:7-dimethylquinoline and based on the quinine model are described. Three of the substances containing the 2-phenyl-6:7-dimethylquinoline nucleus show antiplasmodial activity on malaria in canaries much superior to the activity of quinine. The 6:7-dimethyi groups present in these compounds show a structural affinity with riboflavin but the antiplasmodial results are not favourable to the view that riboflavin-antagonism plays any significant part in the mechanism of action of these active bases.Keywords
This publication has 2 references indexed in Scilit:
- Studies in the Quinoline Series. II. The Preparation of Some Dialkylaminomethyl-4-quinoline Methanols1,2Journal of the American Chemical Society, 1946
- 141. New potential chemotherapeutic agents. Part V. Basically-substituted isoalloxazinesJournal of the Chemical Society, 1946