Dietary rescue of a lethal ?null? activity allele of 6-phosphogluconate dehydrogenase in Drosophila melanogaster
- 1 June 1978
- journal article
- research article
- Published by Springer Nature in Biochemical Genetics
- Vol. 16 (5-6) , 469-475
- https://doi.org/10.1007/bf00484212
Abstract
The genetic rescue of Pgd n lethal alleles, accomplished by combining them with mutations lacking glucose-6-phosphate dehydrogenase activity, has led to the hypothesis that Pgd n lethality may be due to the accumulation of 6-phosphogluconate. In this article we report the rescue of Pgd n /Y males by dietary supplements (fructose and linolenate) designed to minimize 6-phosphogluconate production.This publication has 10 references indexed in Scilit:
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