EXPERIMENTAL OCCLUSION OF THE PULMONARY ARTERY

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Abstract
The increasingly frequent occurrence of postoperative pulmonary embolism with its dreaded and often fatal results is probably responsible for the stimulation of interest in the subject of experimental occlusion of the pulmonary artery. Numerous investigators have approached the subject from as many different angles. The literature has been reviewed by Schlaepfer.1 Experiments performed by this investigator on rabbits and dogs showed that ligations of a branch of the pulmonary artery did not result in marked fibrosis as had been shown by Bruns,2 Sauerbruch,3 Kawamura,4 Smirnoff5 and others. Schlaepfer did produce extensive fibrosis, however, by cutting the phrenic nerve when ligating the corresponding pulmonary artery. Schlaepfer's experiments on dogs were carried out, however, through a transpleural approach. In the experiments on rabbits the branch of the pulmonary artery was ligated through a pericardotomy opening without causing pneumothorax. In any mechanism so complicated as that of the

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