Orthoxine in Bronchial Asthma

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Abstract
SINCE the elucidation by Chen and Schmidt1 (1923) of the chemical structure and the pharmacologic effects of ephedrine, this drug has ranked with epinephrine as one of the most valuable medications for the treatment of bronchial asthma. Although less active as a bronchodilator than epinephrine, ephedrine is effective, and its action is prolonged. However, undesirable effects such as nervousness, tremulousness, sleeplessness, vertigo, sweating, anorexia, nausea and palpitation often interfere with the use of the drug or require the additional administration of sedatives. In the last few years, therefore, attempts have been made to produce sympathomimetic compounds with less effect on . . .