Splenectomy in Leukemia and Myelofibrosis: Changes in the Erythrocyte Values

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Abstract
The enlarged spleen of leukemic patients and patients suffering from myelofibrosis is capable of trapping and often destroying a large num-ber of red cells. This is the major mechanism of anemia in leukemia, and occurs more often without demonstrable presence of circulating antibodies. The study of the output of stercobilinogen and of the survival of red blood cells in the circulation before and after splenectomy demonstrates that the majority of patients who have an increase of the total circulating hemoglobin manifest, after splenectomy, a diminished output of stercobilinogen and a better survival of red blood cells in circulation. The erythroblastic population of the bone marrow remains unchanged.

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