MIXTURES OF LOCAL-ANESTHETICS - BUPIVACAINE-CHLOROPROCAINE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 59  (9) , 683-685
Abstract
Experiments were performed in a rat sciatic nerve preparation to determine the characteristics of nerve blocks produced by a combination of commercially available solutions of bupivacaine and chloroprocaine. A mixture of equal parts or commercially available chloroprocaine 2% and bupivacaine 0.5% caused a nerve blockade with characteristics of a chloroprocaine block. Changing the pH value of this mixture from 3.60-5.56 changed the characteristics to a blockade resembling that produced by bupivacaine. The nerve blockades obtained by mixing commercially available solutions of local anesthetics are unpredictable and may depend on a number of factors which include not only the types of drugs but the pH of the mixture.