Concentrations of ciprofloxacin in human liver, gallbladder, and bile after oral administration
- 1 January 1987
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 32 (2) , 217-218
- https://doi.org/10.1007/bf00542200
Abstract
We have measured concentrations of ciprofloxacin in serum, hepatic tissue, gallbladder, and bile in 10 patients after a single oral dose of 750 mg given before cholecystectomy. Mean liver and gallbladder tissue concentrations were 12.76 µg·g−7±2.79 (SEM) and 5.94 µg·g−1±1.35, respectively. Concentrations in bile taken from the gallbladder (7 patients) ranged from 68 to 225 µg·ml−1, with a mean bile/serum concentration ratio of 49. Concentrations in bile taken from the common bile duct (2 patients) were 17 and 16 µg·ml−1.This publication has 4 references indexed in Scilit:
- The fluoroquinolones: structures, mechanisms of action and resistance, and spectra of activity in vitroAntimicrobial Agents and Chemotherapy, 1985
- Comparison of high-pressure liquid chromatography and microbiological assay for the determination of biliary elimination of ciprofloxacin in humansAntimicrobial Agents and Chemotherapy, 1985
- Ciprofloxacin, a quinolone carboxylic acid compound active against aerobic and anaerobic bacteriaAntimicrobial Agents and Chemotherapy, 1984
- Efficacy of antibiotics in bacteriobiliaJournal of Antimicrobial Chemotherapy, 1982