Regioselective Substitution of Fluorine in F8BINOL as a Versatile Route to New Ligands with Axial Chirality
- 5 October 2000
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 2 (22) , 3433-3436
- https://doi.org/10.1021/ol006428k
Abstract
Nucleophilic substitution of aromatic fluorine in F8BINOL offers the possibility of selectively introducing a variety of substituents at the 6, 6‘, 7, and 7‘ positions. The configurational integrity of the homochiral precursors is maintained under the conditions described, allowing one to carry out these modification protocols on a microscale without the need for subsequent resolution steps. The resulting chiral ligands have been investigated as precursors to new asymmetric catalysts.Keywords
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