Body Temperature Responses of Aged Mice to Ambient Temperature and Humidity Stress

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Abstract
Male C57BL/6 mice aged 6 to 7 months, 13 to 14 months, and 19 to 20 months were acutely exposed to four ambient temperature (15 °C, 20 °C, 30 °C, 35 °C) and two relative humidity (50%rh, 80%rh) conditions. Three-hour average rectal temperatures were compared across age groups and environmental conditions. At the two temperature extremes of 15 °C and 35 °C, there was a very marked age-associated hypothermia and hyperthermia, respectively. This hypothermic response was maintained by the 19 to 20-month-old mice during exposure to 20 °C and thermoneutrality (30 °C). At any given ambient temperature, relative humidity had no effect on thermoregulatory function in the oldest mice, whereas the 6 to 7-month-and 13 to 14-month-old mice were sensitive to the effects of humidity at 15 °C and 20 °C.

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