Genetic Prognostic Markers for Colorectal Cancer

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Abstract
Genetic testing is increasingly being used in the management of cancer. Cytogenetic and molecular genetic assays now play a part in the diagnosis and monitoring of a variety of leukemias, lymphomas, and solid tumors. Moreover, the identification of inherited mutations of genes that cause susceptibility to cancer provides new tools for the prevention and early detection of cancer.1 The study by Gryfe et al. in this issue of the Journal concerns the prognostic importance of a genetic abnormality (microsatellite instability) that occurs not only in hereditary nonpolyposis colorectal cancer but also in colorectal tumors in young patients (50 years of . . .