Improved Solid-Phase Synthesis of Tryptophan-Containing Peptides. I. Use of Hydrogen Chloride in Formic Acid as a Reagent for the Cleavage of t-Butyloxycarbonyl Group
- 1 September 1972
- journal article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 45 (9) , 2852-2855
- https://doi.org/10.1246/bcsj.45.2852
Abstract
An improved method has been described for the solid-phase synthesis of tryptophan-containing peptides. Hydrogen chloride in formic acid has been introduced as a reagent for the cleavage of the t-butyloxycarbonyl group owing to the stableness of tryptophan and Ni-formyltryptophan in this system. The effectiveness of the new reagent has been demonstrated in the synthesis of the tryptophan-containing heptapeptide, lysylalanylglycyl-leucylglycyltryptophylleucine.This publication has 15 references indexed in Scilit:
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