REGULATION OF NORADRENALINE OVERFLOW IN RAT CEREBRAL CORTEX BY PROSTAGLANDIN E2
Open Access
- 1 November 1980
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 70 (3) , 469-473
- https://doi.org/10.1111/j.1476-5381.1980.tb08725.x
Abstract
1 The effects of prostaglandin E2 (PGE2), PGF2α and PGI2 and of inhibitors of prostaglandin synthesis and action, on the K+-evoked [3H]-noradrenaline ([3H]-NA) overflow from rat cerebral cortex slices have been investigated. 2 PGE2 reduced, while indomethacin (a prostaglandin synthesis inhibitor) or SC 19220 (a prostaglandin receptor antagonist) increased, the evoked overflow compared with controls. 3 The inhibition of [3H]-NA overflow by PGE2 was dose-dependently antagonized by SC 19220. 4 The results indicate that PGE2 modulates NA release in rat cerebral cortex in vitro.Keywords
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