Chromosomal abnormalities in T‐cell large granular lymphocyte leukaemia: report of two cases and review of the literature

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Abstract
Summary. Cytogenetic information on T‐cell large granular lymphocyte leukaemia (T‐LGL; large granular lymphocytosis) is limited. We report two cases of T‐LGL with unusual karyotypic aberrations. The first case showed a novel inv(7)(p15q22) as the sole chromosomal abnormality, while the second case showed an inv(14)(q11q32) with evidence of clonal evolution. The breakpoints 7p14–p15 and 14q11 coincide with the T‐cell receptor (TCR)‐γ and TCR‐α/TCR‐δ gene loci respectively. This is the first report describing the possible involvement of T‐cell receptor genes in karyotypic aberrations in T‐LGL.