A Single-Copy Gene Encodes Kex1, a Serine Endoprotease of Pneumocystis jiroveci

Open Access

1 January 2003

journal article
Published by American Society for Microbiology in Infection and Immunity

Vol. 71 (1) , 571-574
https://doi.org/10.1128/iai.71.1.571-574.2003

Abstract

We have cloned and characterized the kex1 gene of Pneumocystis jiroveci. Unlike the case for Pneumocystis carinii, in which the homologous PRT-1 genes are multicopy, kex1 is a single-copy gene encoding a protein homologous to fungal serine endoproteases, which localize to the Golgi apparatus. Thus, substantial biological differences can be seen among Pneumocystis species.

Keywords

This publication has 32 references indexed in Scilit:

Genetic Divergence of the Dihydrofolate Reductase and Dihydropteroate Synthase Genes inPneumocystis cariniifrom 7 Different Host Species
The Journal of Infectious Diseases, 2001
Pneumocystis cariniiDihydropteroate Synthase but Not Dihydrofolate Reductase Gene Mutations Correlate with Prior Trimethoprim‐Sulfamethoxazole or Dapsone Use
The Journal of Infectious Diseases, 1999
Characterization of a Multicopy Family of Genes Encoding a Surface‐Expressed Serine Endoprotease in Rat Pneumocystis carinii
Proceedings of the Association of American Physicians, 1999
A Pneumocystis carinii multi-gene family with homology to subtilisin-like serine proteases
Microbiology, 1997
Isoform Diversity and Tandem Duplication of the Glycoprotein A Gene in Ferret Pneumocystis carinii
DNA Research, 1995
Molecular Genetic Distinction ofPneumocystis cariniifrom Rats and Humans
The Journal of Eukaryotic Microbiology, 1993
The pro‐region of the Kex2 endoprotease of Saccharomyces cerevisiae is removed by self‐processing
FEBS Letters, 1992
Intracellular Targeting and Structural Conservation of a Prohormone-Processing Endoprotease
Science, 1989
Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor
Cell, 1984
An Outbreak of Community-AcquiredPneumocystis cariniiPneumonia
New England Journal of Medicine, 1981