A Cross-over Study Comparing the Kinetics of Tc-99m-labeled Diisopropyl and P-Butyl IDA Analogs in Patients

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Abstract
Tc-99m-diisopropyl-imino-diacetic acid (DISIDA) and Tc-99m-p-butyl-IDA (BIDA); used in hepatobiliary imaging, were compared in each of 33 patients who had serum bilirubins ranging from normal to 23.5 mg/dl. DISIDA exhibited a quantitatively higher liver uptake and faster rate of washout at all levels of bilirubinemia. There was a tendency for BIDA to have a slower blood clearance, particularly in hyperbilirubinemias exceeding 5 mg/dl. On visual comparison of the images, BIDA failed to identify the gallbladder in 3 icteric patients and dilated biliary tracts in 2 others.

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