Structure of influenza haemagglutinin at the pH of membrane fusion
- 1 September 1994
- journal article
- Published by Springer Nature in Nature
- Vol. 371 (6492) , 37-43
- https://doi.org/10.1038/371037a0
Abstract
Low pH induces a conformational change in the influenza virus haemagglutinin, which then mediates fusion of the viral and host cell membranes. The three-dimensional structure of a fragment of the haemagglutinin in this conformation reveals a major refolding of the secondary and tertiary structure of the molecule. The apolar fusion peptide moves at least 100 A to one tip of the molecule. At the other end a helical segment unfolds, a subdomain relocates reversing the chain direction, and part of the structure becomes disordered.Keywords
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