The change of disposition kinetics for creatinine and urea accompanied by growth in mice.

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Abstract
To clarify the change of disposition kinetics accompanied by growth, the whole-blood levels and whole-body autoradiography following i.v. administration of creatinine and urea, which are considered to pass through the water-filled pores of biological membranes easily, were investigated in 1-day-old, 1-, 3- and 8-wk-old mice. For both creatinine and urea, the total body clearance was considerably lower in 1-day-old and 1-wk-old mice than in older mice. Relatively lower renal clearance (i.e., rather incomplete renal function) in 1-day-old and 1-wk-old mice was probably the major reason. The lower metabolic clearance also seemed to be the cause in the case of urea, because the expiratory excretion of 14CO2 following i.v. administration of 14C-urea was almost negligible in 1-day-old and 1-wk-old mice in contrast to older mice (16-21%). The whole-body autoradiograms obtained following i.v. administration of 14C-creatinine indicated that creatinine was more rapidly transferred from blood to muscle in 1-day-old and 1-wk-old mice, especially in 1-day-old mice, than in more aged mice. This might be caused by the difference in muscular blood flow rate or muscular cell membrane permeability to creatinine.

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