Hypotensive sequelae of diazoxide and hydralazine therapy

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Abstract
Combinations of diazoxide and other vasodilatory or catecholamine-depleting agents may result in extreme hypotension. Four cases are presented in whom severe hypotension followed diazoxide therapy. In each case, another vasodilatory agent, hydralazine hydrochloride, was administered in close sequence to diazoxide therapy. Diazoxide has been reported to be a safe and effective agent in the treatment of hypertensive emergencies, but causes a fall in peripheral vascular resistance and a concomitant increase in heart rate, cardiac index and left ventricular ejection rate. Diazoxide should be administered with caution to patients being concurrently treated with other potential vasodilatory or catecholamine-depleting agents.

This publication has 1 reference indexed in Scilit:

  • Diazoxide
    New England Journal of Medicine, 1976