THE DEVELOPMENTAL PATTERN OF IN VITRO RAT LIVER MELATONIN DEGRADING ACTIVITY
- 1 March 1981
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 108 (3) , 1081-1082
- https://doi.org/10.1210/endo-108-3-1081
Abstract
The developmental pat-tern of the in vitro rat liver melatonin degrading activity was studied. Livers from rats 3, 12, 16, 21, 30 and 90 days old were incubated with [3H] melatonin. A high pressure liquid chromatography (HPLC) technique was used to determine the appearance of melatonin metabolic product–6–hydroxymelatonin– in the liver extract. Catabolic activity being very low at age 3 days, increased rapidly with age and reached maximum activity between the ages 21 to 30 days.Keywords
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