Diffuse fasciitis with eosinophilia

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Abstract
The recently described syndrome of diffuse fasciitis with eosinophilia consisted of scleroderma-like cutaneous changes in the absence of Raynaud''s phenomenon and without visceral involvement. Peripheral blood eosinophilia and hypergammaglobulinemia occurred in the majority of patients. The biopsy specimen was characteristic and showed a diffusely thickened fascia with a noticeable inflammatory infiltrate. The etiology and pathogenesis of the entity are unknown. The majority of the cases were reported to respond to corticosteroids. Pulmonary function abnormalities and rheumatoid factor elevation in 1 of the patients suggested that this syndrome may be a variant of scleroderma or may have previously unrecognized systemic manifestations. The patients'' objective responses to corticosteroids were minimal.

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