Effect of beta1 selective adrenoceptor blockade on physiological response to exercise.

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Abstract
The effect of the beta1 selective adrenoceptor blocker, atenolol, on the physiological response to exercise was studied in 12 healthy young men. Oral atenolol (100 mg) and placebo were administered in a randomized double blind crossover fashion 1.5 h before an intermittent multistage cycle ergometer exercise test. At maximal effort O2 consumption, pulmonary ventilation, CO2 output and respiratory exchange ratio were not modified by atenolol. In contrast, maximal heart rate and performance time were significantly reduced after atenolol. Because the relation of percentage of maximal O2 comsumption to percentage of maximal heart rate was not changed by atenolol, both the absolute and relative O2 consumption corresponding to 70% and 85% of the maximal heart rate remained unaltered. Exercise intensity may be determined on the basis of a calculated percentage of the predetermined maximal heart rate in persons without symptomatic coronary heart disease receiving beta1 selective adrenoceptor blockers.