Influence of an acetylsalicylic anhydride impurity on the rate of dissolution of acetylsalicylic acid

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Abstract
The intrinsic dissolution rate of acetylsalicylic acid in 0·1 n hydrochloric acid at 35° has been shown by a rotating disc method to be affected by the presence of acetylsalicylic anhydride in the crystals. At concentrations exceeding 0·25% the impurity decreased the dissolution rate of the acetylsalicylic acid. It is suggested that the previously reported differences in rates of dissolution of various commercial and recrystallized acetylsalicylic acid preparations may be due to differences in content of acetylsalicylic anhydride which is a frequently-occurring impurity in commercial acetylsalicylic acid and is formed on heating solutions of acetylsalicylic acid in various organic solvents.

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