Length distribution of CDRH3 in antibodies
- 1 May 1993
- journal article
- review article
- Published by Wiley in Proteins-Structure Function and Bioinformatics
- Vol. 16 (1) , 1-7
- https://doi.org/10.1002/prot.340160102
Abstract
Sequences of the third complementarity determining region of antibody heavy chains (CDRH3s) are listed according to their length. Human sequences vary from 2 to 26 amino acids residues, but less extensively in other species. When combined with the other five complementarity determining regions, this enormous length variation of CDRH3, together with amino acid substitutions in their sequences, can provide a very large number of antibody specificities and can influence the shape of antibody combining sites.©1993 Wiley‐Liss,Inc.Keywords
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