SOME ASPECTS OF PHARMACOKINETIC AND BIOTRANSFORMATION DIFFERENCES IN HUMANS AND MAMMAL ANIMALS
- 1 January 1978
- journal article
- research article
- Vol. 16 (8) , 357-360
Abstract
The erroneous tendency to set pharmacokinetics and biotransformation of drugs in man against results obtained in animals as a different homogenous group is discussed. Species differences have mainly a quantitative character, such as the body weight to surface ratio, organ weight to body weight ratio, presence of differing fat deposits, etc. Qualitative differences are not so common. The great importance of a better knowledge of these problems for the prediction of drug effects in man from results obtained in animals is emphasized.This publication has 6 references indexed in Scilit:
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