Renal Dysfunction Complicating the Treatment of Hypertension
Top Cited Papers
- 17 October 2002
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 347 (16) , 1256-1261
- https://doi.org/10.1056/nejmra020676
Abstract
In patients with hypertension and renal insufficiency, there is often an increase in the serum creatinine concentration as the blood pressure is lowered. Physicians may respond by reducing antihypertensive treatment. However, as this review explains, the decline in renal function is hemodynamic in origin and is due to changes in renal autoregulation. Such an increase in creatinine should be recognized as a sign that the intraglomerular pressure has been successfully reduced, and the physician should continue antihypertensive treatment.Keywords
This publication has 35 references indexed in Scilit:
- Impaired Renal Autoregulation: Implications for the Genesis of Hypertension and Hypertension-Induced Renal InjuryThe Lancet Healthy Longevity, 2001
- Impaired autoregulation of the glomerular filtration rate in patients with nondiabetic nephropathiesKidney International, 1999
- The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressureArchives of internal medicine (1960), 1997
- Altered myogenic responsiveness of the renal microvasculature in experimental hypertensionJournal Of Hypertension, 1996
- Proceedings of the Symposium ‘Angiotensin AT1 Receptors: From Molecular Physiology to Therapeutics’: PRESENCE OF ANGIOTENSIN II AT2 RECEPTOR BINDING SITES IN THE ADVENTITIA OF HUMAN KIDNEY VASCULATUREClinical and Experimental Pharmacology and Physiology, 1996
- Increased glomerular filtration rate after withdrawal of long-term antihypertensive treatment in diabetic nephropathyKidney International, 1995
- Renal ablation acutely transforms 'benign' hypertension to 'malignant' nephrosclerosis in hypertensive rats.Hypertension, 1994
- Impaired autoregulation of glomerular capillary hydrostatic pressure in the rat remnant nephron.Journal of Clinical Investigation, 1991
- Renal histopathology in hypertensive diabetic patients.Hypertension, 1985
- Autoregulation of cerebral blood flow in hypertensive patients. The modifying influence of prolonged antihypertensive treatment on the tolerance to acute, drug-induced hypotension.Circulation, 1976