SLOW INWARD AND OUTWARD CURRENTS OF RAT VENTRICULAR FIBERS UNDER ANOXIA

  • 1 January 1978
    • journal article
    • research article
    • Vol. 74  (1) , 31-35
Abstract
Voltage and current clamp experiments were performed on rat ventricular strips under anoxia. Under the influence of anoxia the membrane depolarized by 5-10 mV and the action potential amplitude decreased by 15 mV. The plateau disappeared and the duration of the action potential was shortened. The slow inward current was reduced by 50-80% and its reversal potential became more negative by about 31 mV. The conductance of the slow inward channel decreased by 26%. The net outward current was slightly depressed.

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