Costaricine, a New Antiplasmodial Bisbenzylisoquinoline Alkaloid from Nectandra salicifolia Trunk Bark
- 1 January 1996
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 59 (6) , 576-580
- https://doi.org/10.1021/np960195h
Abstract
A MeOH extract of Nectandra salicifolia trunk bark, obtained during a diversity-based plant collection in a lower montane rainforest in Costa Rica, showed activity in an in vitro antiplasmodial assay measuring incorporation of [3H]-labeled hypoxanthie by Plasmodium falciparum. In addition to 15 known alkaloids isolated from samples of trunk bark, roots, and leaves/twigs of this species, a new bisbenzylisoquinoline alkaloid (+)-costaricine [(+)-12-O-methyllindoldhamine] (1) was isolated from bark (0.038% yield) and from roots (0.001%). (+)-Costaricine was active in the antiplasmodial assay, with IC50 values of 50 ng/mL vs. the chloroquine-sensitive D6 clone and 294 ng/mL vs. the chloroquine-resistant W2 clone of P. falciparum.Keywords
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