An Archaeal Aminoacyl-tRNA Synthetase Missing from Genomic Analysis
Open Access
- 15 September 1999
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 181 (18) , 5880-5884
- https://doi.org/10.1128/jb.181.18.5880-5884.1999
Abstract
The complete genomic sequencing of Methanococcus jannaschii cannot identify the gene for the cysteine-specific member of aminoacyl-tRNA synthetases. However, we show here that enzyme activity is present in the cell lysate of M. jannaschii . The demonstration of this activity suggests a direct pathway for the synthesis of cysteinyl-tRNA Cys during protein synthesis.Keywords
This publication has 17 references indexed in Scilit:
- Seeking an ancient enzyme in Methanococcus jannaschii using orf , a program based on predicted secondary structure comparisonsProceedings of the National Academy of Sciences, 1998
- Complete Sequence and Gene Organization of the Genome of a Hyper-thermophilic Archaebacterium, Pyrococcus horikoshii OT3DNA Research, 1998
- Complete Sequence and Gene Organization of the Genome of a Hyper-thermophilic Archaebacterium, Pyrococcus horikoshii OT3 (Supplement)DNA Research, 1998
- Archaeal-type lysyl-tRNA synthetase in the Lyme disease spirochete Borrelia burgdorferiProceedings of the National Academy of Sciences, 1997
- A Euryarchaeal Lysyl-tRNA Synthetase: Resemblance to Class I SynthetasesScience, 1997
- Aminoacyl-tRNA synthesis: divergent routes to a common goalTrends in Biochemical Sciences, 1997
- Complete Genome Sequence of the Methanogenic Archaeon, Methanococcus jannaschii Science, 1996
- An unusual RNA tertiary interaction has a role for the specific aminoacylation of a transfer RNA.Proceedings of the National Academy of Sciences, 1993
- Selenoprotein synthesis: an expansion of the genetic codeTrends in Biochemical Sciences, 1991
- In vivo aminoacylation of human and Xenopus suppressor tRNAs constructed by site-specific mutagenesis.Proceedings of the National Academy of Sciences, 1987