An Enantiocontrolled Rotue to Unnatural (+)-Physostigmine
- 1 January 1990
- journal article
- research article
- Published by The Japan Institute of Heterocyclic Chemistry in HETEROCYCLES
- Vol. 31 (3) , 411-414
- https://doi.org/10.3987/com-89-5284
Abstract
Ent-Esermethole (3), enantiomer of the key intermediate of physostigmine (1) and its other congeners, has been synthesized starting from the known optically active dihydronaphthalene (6) obtained via lipase mediating asymmetric hydrolysis.Keywords
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- Comparison of (-)-eseroline with (+)-eseroline and dihydroseco analogs in antinociceptive assays: confirmation of rubreserine structure by x-ray analysisJournal of Medicinal Chemistry, 1986