Concentrations of Calcitonin Gene-Related Peptide and Neuropeptide Y in Plasma Increase During Flushes in Postmenopausal Women
- 1 January 2000
- journal article
- research article
- Published by Wolters Kluwer Health in Menopause
- Vol. 7 (1) , 25-30
- https://doi.org/10.1097/00042192-200007010-00005
Abstract
To assess whether the plasma concentrations of calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), or neurokinin A (NKA) increase during hot flushes in postmenopausal women with vasomotor symptoms. Eight postmenopausal women (age range = 49-63 years) with vasomotor symptoms were included. During 1 day, repeated blood samples were taken between and during flushes; four samples were taken during each flush. The samples were analyzed for CGRP, NPY, and NKA using radioimmunoassay technique. The serum concentrations of CGRP and NPY increased significantly-73% and 34%, respectively-during the flushes (p = 0.018; p = 0.028), whereas the concentrations of NKA did not change significantly. CGRP and NPY may be involved in the mechanisms that cause vasomotor symptoms. (Menopause 2000;7:25-30. © 2000, The North American Menopause Society.)Keywords
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