Comparison of the Invesligalional drug, LV146032, with vancomycin in experimental pneumonia due to methidillln-resistant Staphylococcus aureus

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Abstract
The eflicacy of LY146032 was compared with that of vancomycin in experimental pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA). Emphysematous hamsters were challenged intratracheally with MRSA and given LY146032 (20 mg/kg 24 h), vancomycin (40 mg/kg/24 h) or normal saline by subcutaneous injection. Following infection with 2 × 109 cfu, survival among antibiotic-treated animals was significantly greater than that of the control group (P9 cfu) or low inoculum (1 × 106 cfu). Animals treated with LY146032 demonstrated a significant advantage in pulmonary clearance versus controls at both inocula however, animals treated with vancomycin showed a statistically significant increase in pulmonary clearance versus controls only at the lower inoculum. We conclude that in this experimental model, LY146032 was as effective as vancomycin in treating infection with MRSA.