Effects of chemical stimulation of the midbrain reticular formation on appetitive behavior.

Abstract
Implant-produced bilateral lesions in the [rat] midbrain reticular formation reliably facilitated the acquisition and performance of simple appetitive habits in maze as well as operant conditioning situations. Cholinergic stimulation of the same site reliably impaired behavior in all appetitive test situations during acquisition as well as at the asymptote of performance. Initial or infrequently repeated cholinergic stimulations produced markedly larger effects than daily administrations. These effects are discussed in relation to previous observations of directly opposite results in aversive test situations.

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