REORGANIZATION IN CULTURE OF THYROID FOLLICULAR CELLS - INFLUENCE OF COLLAGEN ON THE ORIENTATION OF CELL POLARITY

  • 1 January 1980
    • journal article
    • research article
    • Vol. 291  (1) , 79-81
Abstract
In contract with a collagen gel, porcine thyroid follicular cell form a basal pole. A monolayer, with the apical side facing the culture medium is formed when cells are seeded on a collagen layer. In contrast cells reorganize into follicle-like structures when they are embedded in the collagen gel. If vesicles which have their apical pole in contact with the culture medium are embedded in the gel, collagen-cell interaction induces the inversion of cell polarity giving follicular structures. In addition after being overlaid with a collagen layer, cells forming a monolayer reorganize into follicles. The apical pole is formed on the free surface of the monolayer or on the internal side of structures embedded in collagen which differentiate into follicles.