Carbon-13 nuclear magnetic resonance spectra of N-, O-, and S-methylated uracil and thiouracil derivatives

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Abstract
13C NMR chemical shifts were recorded for a number of uracil, thiouracil and pyrimidine derivatives. These data are discussed in relation to the lactam-lactim tautomerism in such systems and possible correlations of chemical shifts with normal aromatic substituent chemical shift parameters. The chemical shifts for the CH3 groups in simple methylated derivatives of uracil are very characteristic of the site of methylation and should prove useful as a tool for assigning structures to alkylated derivatives of this general type.