HUMAN SERUM AND PLASMA INCREASE MOUSE MORTALITY IN STAPHYLOCOCCUS AUREUS INTRAPERITONEAL INFECTION

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Abstract
The influence of human plasma, serum, purified fibrinogen and fibronectin on S. aureus i.p. infection in nonimmune mice was studied. Mouse mortality was used as a measure of staphylococcal virulence. Both human plasma and serum were shown to enhance the virulence of S. aureus strain E 2371 and strain E 2476 when added to the bacteria before challenge. This effect of serum was unaffected by storage for 24 h at 37.degree. C or complement-inactivation for 1 h at 56.degree. C. Purified fibrinogen and fibronectin did not influence the S. aureus virulence. Evidently, the effects of plasma and serum described here might play a role in the establishment of S. aureus infections in humans.

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