ON THE METABOLISM OF METHYLATED DISULPHONAMIDES WITH A DIURETIC ACTION—A CONTRIBUTION TO THE MECHANISM OF ACTION OF CHLOROTHIAZIDE AND SIMILAR COMPOUNDS

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Abstract
The metabolism of two substances possessing a diuretic action, 4-amino-6-chloro-benzene-1,3-disulphonmethylamide (III) and 6-chloro-3,4-dihydro-2-methyl-7-methyl-sulphamoyl-2H-1,2,4-benzo[e]thiadiazine-1,1-dioxide (IV), has been studied on rats and human subjects. It has been shown that these compounds are not demethylated in the –SO2.NHCH3 group. They therefore do not act through liberation of substances with unsubstituted sulphonamido-groups which might inhibit carbonic anhydrase, and their mechanism of diuretic action cannot be considered due to inhibition of this enzyme.