Neoplasms arising in congenital giant nevi
- 1 March 1981
- journal article
- research article
- Published by Wolters Kluwer Health in The American Journal of Surgical Pathology
- Vol. 5 (2) , 109-135
- https://doi.org/10.1097/00000478-198103000-00004
Abstract
Congenital giant nevi are complex cutaneous malformations composed of melanocytic and occasionally neural supportive elements. Malignant neoplasms arising in this setting are not uncommon and their histologic appearances often differ significantly from the typical pattern of malignant melanoma. Six patients with neoplasms arising in congenital giant nevi and 1 patient with a neoplasm arising in an extensive congenital blue nevus are reported. The neoplastic patterns encountered include poorly differentiated small round cell cancer, malignant cellular blue nevus, spindle-cell malignant tumor with lamellar cell (pseudomeissnerian) differentiation, minimal deviation melanoma, heterologous malignant mesenchymal differentiation (including rhabdomyosarcoma and liposarcoma) and undifferentiated spindle cell cancer. The literature was reviewed in order to address the question of frequency of malignant transformation in congenital giant nevi, the reported experience with the morphology of these cancers and the histogenesis of these sometimes complex neoplasms as it is illuminated by the current understanding of the embryology of the neural crest.This publication has 16 references indexed in Scilit:
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