Drug Interactions of Levamisole with Pyrantel Tartrate and Dichlorvos in Pigs
Open Access
- 1 November 1981
- journal article
- research article
- Published by American Veterinary Medical Association (AVMA) in American Journal of Veterinary Research
- Vol. 42 (11) , 1912-1914
- https://doi.org/10.2460/ajvr.1981.42.11.1912
Abstract
SUMMARY: The ld50 from subcutaneous administration of levamisole in castrated male pigs (15 to 25 kg) was established as 39.8 mg/kg. Oral administration of dichlorvos (60 mg/kg, 3 times the anthelmintic dosage level) 1 hour before levamisole injection lowered blood cholinesterase activity to approximately 60% that of the controls, but did not change the ld50 of levamisole. In contrast, oral administration of pyrantel tartrate (25 mg/kg, an anthelmintic dosage level) did not lower blood cholinesterase activity, but rather, increased the toxicity by lowering the ld50 of levamisole from 39.8 mg/kg to 27.5 mg/kg. The data supported the hypothesis that levamisole toxicity was enhanced by nicotine-like compounds (ie, pyrantel), but was not affected by organophosphates (ie, dichlorvos).This publication has 0 references indexed in Scilit: